Özdinler received a Master’s degree in a program spanning chemical engineering and molecular biology and genetics focusing on biotechnology. Lurie Comprehensive Cancer Center, and the Les Turner ALS Center. She is also a member at the Mesulam Cognitive Neurology and Alzheimer’s Disease Center, the Robert H. Hande Özdinler, PhD, is an Associate Professor at the Department of Neurology, Northwestern University, Feinberg School of Medicine. “It also enables me to contribute to Northwestern’s research community on preclinical development of new drugs and novel devices, and to facilitate the transition of novel discoveries to clinical applications.” “CLP offers me the best opportunity to collaborate with other outstanding investigators on multiple research topics of cancer research,” says Li. He completed a postdoctoral fellowship studying gene expression in cancer at Baylor College of Medicine. Li earned his PhD and MD, and completed his residency and fellowship at Suzhou Medical College/Soochow University in China. Li will leverage his vast experience as the new Faculty Director of CLP’s Developmental Therapeutics Core where he will apply his expertise conducting comprehensive preclinical drug testing to establish rational for the initiation of clinical trials for promising research programs. An expert in developing novel patient-derived orthotopic xenograft mouse models to understand tumor biology and identify new diagnostic and/or therapeutic targets, Li pioneered the development of clinically relevant and molecularly accurate animal models of pediatric brain tumors, and has developed 130 models of different brain tumor subtypes. As a freshly minted faculty member, Gabe brings a whole repertoire of protein design tools that are based on molecular modeling and evolutionary principles.”Īs Director of Pediatric Xenograft Modeling at the Manne Research Institute at Lurie Children’s Hospital, Xiao-Nan Li, an acclaimed cancer biologist, focuses on finding improved therapies for children with cancer. Xiao-Nan brings a wealth of expertise in animal models of disease and development of new treatments. “Hande is doing brilliant work on understanding the molecular basis of neurodegenerative diseases like ALS and has formed some extraordinary collaborations with Rick Silverman. “It’s very exciting to have three members of the Feinberg faculty join the Institute,” says Thomas O’Halloran, Founding Director of the Institute. The Institute’s new members are Xiao-Nan Li, MD, PhD, Professor of Pediatrics (Hematology, Oncology, and Stem Cell Transplantation) Hande Özdinler, PhD, Associate Professor of Neurology and Gabriel Rocklin, PhD, Assistant Professor of Pharmacology. PIs uncertain of the suitability of their proposals are encouraged to contact a CLP Program Officer.This fall, three members of Northwestern University’s Feinberg School of Medicine joined Chemistry of Life Processes Institute to strengthen opportunities for collaboration across disciplines and translation of their groundbreaking work. Note: The CLP Program is not interested in projects that are disease-related or that have drug discovery/design/development goals. Other topics of interest include: the development and application of bio-orthogonal chemistry for probing cellular function biomolecular design and synthesis aimed at understanding biological function the use of theory, computation, modeling and simulation as applied to the chemical aspects of biological systems and chemical aspects that underlie the function of the brain.
Chemical methods development is also acceptable when such methods are applied to answering specific biological questions.
Research projects must use or create innovations in chemistry that advance the understanding of biological function. Subject areas include bioorganic and bioinorganic chemistry chemical biology lipids, membranes and membrane-proteins and protein, enzyme, nucleic acid and carbohydrate chemistry. The scope of the program is broad, reflecting the power of chemistry and diversity of biology. The proposed research should be based on innovation(s) in chemistry and address an important question about a biological process. Such studies would promote the fundamental understanding of the molecular underpinnings of life processes. The Chemistry of Life Processes (CLP) Program supports fundamental experimental and computational studies at the interface of chemistry and biology.
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